Anxiety and depression in patients with Parkinson’s disease selected for magnetic resonance-guided focused ultrasound thalamotomy

O. Kachemaeva, R. Galimova, D. Krekotin, Y. Sidorova, I. Buzaev, A. Saveliev, N. Mukhamadeeva,
G. Akhmadeeva (Ufa, Russian Federation)

Meeting: MDS Virtual Congress 2021
ABSTRACT NUMBER: 957
Keywords: Anxiety, Depression, Parkinson’s
Category: Parkinson’s Disease: Non-Motor Symptoms
Objective: To assess the severity of anxiety and depression in patients selected for treatment with the magnetic resonance-guided focused ultrasound thalamotomy (MRgFUS TT) before the therapy (1, 2, 3).Background: Anxiety (A) and depression (D) in patients with Parkinson’s disease (PD) are underestimated and not paid enough attention conditions, which could interfere with treatment.

Method: 19 patients with PD were evaluated with Hospital Anxiety and Depression Scale (HADS), Montreal Cognitive Assessment scale (MoCA) before they underwent MRgFUS TT.

Results: 4 women and 15 men were enrolled, mean age 61.78 years old (min – 38 y.o., max- 81y.o.). Median of disease duration was 6.38 years (min-2, max-13), median MoCA points were 25.73 (min – 21, max–30). A and
D were found in 6 patients (31.58 %). The median severity of A was 6.26 points (min-1, max-14), of D was 5.68 points (min-0, max-12). A and D within normal ranges were in 13 patients. Clinically remarkable points of A were in 2 patients, of D – in 4 patients. Borderline abnormal ranges of A were in 4 patients, of D – in 1.
The levels of anxiety and depression were not correlated with each other and statistically significant
correlated with disease duration, modified Hoen and Yarh stage (m-HYS), p<0.05. 4 patients with D more than 11 HADS points were in 3 and 4 stages on the m-HYS. 13 patients with normal A and D HADS score were in the 2-2.5 stages on this scale. Limitations of our study: predominance of tremor over rigidity, heterogeneity and small sample size.

Conclusion: A and D are common in PD. It is necessary to evaluate A and D with more detailed and sensitive scales (Montgomery—Asberg Depression Rating Scale, Hamilton scale, Beck scale). It is demanded to increase the sample size and to continue evaluation of A and D in the follow-up period after the MRgFUS TT.
It would be desirable to compare the prevalence of A and D in patients with a predominantly rigid form of PD before and after the MRgFUS TT.

References:

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2. Yang-Pei Changz, Min-Sheng Lee, Da-Wei Wu, Jui-Hsiu Tsai, Pei-Shan Ho, Chun-Hung Richard Lin, Hung-Yi Chuang. Risk factors for depression in patients with Parkinson’s disease: A nationwide nested
case-control study. PLoS One. 2020; 15(7): e0236443.Published online 2020 Jul 27. doi:
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To cite this abstract in AMA style:

O. Kachemaeva, R. Galimova, D. Krekotin, Y. Sidorova, I. Buzaev, A. Saveliev, N. Mukhamadeeva, G. Akhmadeeva. Anxiety and depression in patients with Parkinson’s disease selected for magnetic resonance-guided focused ultrasound thalamotomy. [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/anxiety-and-depression-in-patients-with-parkinsons-disease- selected-for-magnetic-resonance-guided-focused-ultrasound-thalamotomy/. Accessed January 11, 2023.